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Kossiakoff, Anthony

One or more keywords matched the following properties of Kossiakoff, Anthony

Property	Value
keywords	Structural Biology

One or more keywords matched the following items that are connected to Kossiakoff, Anthony

Item Type	Name
Concept	Receptors, Somatotropin
Concept	Receptors, Prolactin
Concept	Receptors, Cell Surface
Concept	Receptors, Vasopressin
Concept	Receptors, Cytoplasmic and Nuclear
Concept	Receptors, Interferon
Concept	Receptors, Adrenergic, beta-2
Concept	Frizzled Receptors
Concept	Receptors, CXCR4
Concept	Receptors, G-Protein-Coupled
Concept	G-Protein-Coupled Receptor Kinase 1
Concept	Receptors, Neurokinin-1
Concept	Receptors, Peptide
Concept	Receptor, ErbB-2
Concept	Receptors, Virus
Concept	Receptors, Neurotransmitter
Concept	Computational Biology
Academic Article	Crystallization and preliminary X-ray analysis of a 1:1 complex between a designed monomeric interferon-gamma and its soluble receptor.
Academic Article	Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Academic Article	Crystallization of ovine placental lactogen in a 1:2 complex with the extracellular domain of the rat prolactin receptor.
Academic Article	Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Academic Article	X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants.
Academic Article	Structural basis for cytokine hormone-receptor recognition and receptor activation.
Academic Article	Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
Academic Article	The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex.
Academic Article	Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization.
Academic Article	Functional promiscuity of squirrel monkey growth hormone receptor toward both primate and nonprimate growth hormones.
Academic Article	The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity.
Academic Article	Crystals of the complex between human growth hormone and the extracellular domain of its receptor.
Academic Article	Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface.
Academic Article	Crystal structure and site 1 binding energetics of human placental lactogen.
Academic Article	Synthetic antibodies for specific recognition and crystallization of structured RNA.
Academic Article	The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled.
Academic Article	Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning.
Academic Article	The X-ray structure of a growth hormone-prolactin receptor complex.
Academic Article	X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
Academic Article	Structure of the growth hormone-receptor complex and mechanism of receptor signaling.
Academic Article	Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors.
Academic Article	Molecular recognition in biological systems: from activation to inhibition.
Academic Article	Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization.
Academic Article	The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors.
Academic Article	An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells.
Academic Article	Structure of active ß-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
Academic Article	Visualization of arrestin recruitment by a G-protein-coupled receptor.
Academic Article	Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling.
Academic Article	Cell biology. New tricks for an old dimer.
Academic Article	Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation.
Academic Article	Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity.
Academic Article	Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Academic Article	Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM.
Award or Honor Receipt	Chair Department of Biochemistry and Molecular Biology
Academic Article	Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
Academic Article	Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Academic Article	A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.
Academic Article	Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Grant	Chaperone Assisted Crystallography
Grant	Chaperone-Enabled studies of epigenetic regulation enzymes
Grant	Energetics of cytokine-induced receptor signaling
Academic Article	Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP.

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Receptor
Biology